Reduction in expression of the astrocyte glutamate transporter, GLT1, worsens functional and histological outcomes following traumatic spinal cord injury
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چکیده
منابع مشابه
Neurobiology of Disease Overexpression of the Astrocyte Glutamate Transporter GLT1 Exacerbates Phrenic Motor Neuron Degeneration, Diaphragm Compromise, and Forelimb Motor Dysfunction following Cervical Contusion Spinal Cord Injury
Ke Li,1* Charles Nicaise,1,2* Daniel Sannie,1 X Tamara J. Hala,1 Elham Javed,1 Jessica L. Parker,1 Rajarshi Putatunda,1 Kathleen A. Regan,1 Valérie Suain,3 Jean-Pierre Brion,3 Fred Rhoderick,4 Megan C. Wright,5 David J. Poulsen,4 and Angelo C. Lepore1 1Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University Medical College, Philadelphia, Pennsylvania 19107, 2...
متن کاملOverexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury.
A major portion of spinal cord injury (SCI) cases affect midcervical levels, the location of the phrenic motor neuron (PhMN) pool that innervates the diaphragm. While initial trauma is uncontrollable, a valuable opportunity exists in the hours to days following SCI for preventing PhMN loss and consequent respiratory dysfunction that occurs during secondary degeneration. One of the primary cause...
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ژورنال
عنوان ژورنال: Glia
سال: 2011
ISSN: 0894-1491
DOI: 10.1002/glia.21241